Our work at the Yorkshire Laser Centre includes clinical trials of the effects of Photodynamic Therapy on different types of cancer. Some of the trials we have recently conducted include;

 

PDT Clinical studies

Indication

Title of study

 

No’s of patients recruited.

 

Lung Cancer

 

Study of the role of PDT in early central lung cancer: pilot study (K Moghissi YLC)

 

30

 

Photodetection

(for early lung cancer)

 

A pilot study of the accuracy of fluorescence bronchoscopy versus white light bronchoscopy in the detection of early bronchogenic cancer in high-risk individuals (K Moghissi YLC)

 

191

 

Oesophageal Cancer

 

Non-randomised comparison between endoscopic PDT and surgical resection in patients with early (stage I) oesophageal cancer (K Moghissi YLC)

 

80 (40 for each arm)

 

Oesophageal Cancer

 

Study to determine the place of endoscopic PDT within the range of treatment for oesophageal cancer. Matched pair subjects (K Moghissi YLC)

 

280 out of 1343 patients

 

 

Gynaecology

 

Study of the role of PDT in VIN: single or multiple PDT cycle (non-randomised prospective) – (C Gan Consultant Gynaecologist NLAG NHS Trust/YLC)

 

30 patients to date

 

Colo-rectal

 

Pilot study of the role of PDT in AIN in patients with or without HIV (G Duthie Dept of Academic Surgery/YLC)

 

26

 

Urology

 

Pilot study of the role of PDT in urothelial cancer ( L Coombs Consultant Urological Surgeon NLAG NHS Trust/YLC)

 

6 patients to date